The Cleveland Discovery and Innovation Forum is a global convening of leaders in engineering, computational technologies, and healthcare and life sciences aimed at landscaping the present and creating the future. This year’s forum, co-designed with the National Science Foundation, will focus on biotechnology anchored in artificial intelligence and quantum computing. The invite-only, 1-day event will dissect the journey from creative ideas to societal health benefits. The forum will bring leaders from academia, industry, and government together to participate in a dialogue grounded in science.